2977: For many years a mighty battle has been raging across the galaxies as 500 billion humans, whose forebears were exiled from Earth, plan to return to what is still called home. Forced to flee a ravaged Earth, humans have now depleted the corners of the galaxy to which they fled. Earth has now become the most valued and precious resource of all, controlled by the corrupt Gaia Coalition which governs the human race across the different galaxies. Having been exiled and vilified during the battle of the Homecoming War, Captain Harlock and his trusted crew of the Arcadia battle cruiser are the only hope mankind has of discovering the secrets that the Gaia have kept hidden. The Coalition has demanded Harlock's death and the Gaia Fleet's new leader, Ezra, calls on his younger brother, Logan, to infiltrate the Arcadia and then assassinate Harlock, thus forever eradicating the one man standing between the Coalition and their complete control of the Universe. Logan must make a very personal...

In the year 2046, it's a new Earth - with new rules. Over thirty years after various alien races arrived on Earth, the landscape is completely altered, terraformed nearly beyond recognition. To the town of Defiance, on what used to be St. Louis, comes the mysterious Nolan (Grant Bowler) and his charge, Irisa (Stephanie Leonidas). As they settle into town - overseen by the mayor, Amanda Rosewater (Julie Benz) and filled with residents like the powerful Rafe McCawley (Graham Greene), enterprising lounge owner Kenya (Mia Kirshner) and the ambitious, alien Tarrs (Tony Curran and Jaime Murray) - events begin to unfold that threaten the fragile peace this border town has fought for.